Foundations of Organometallic Synthesis

Organometallic chemistry is the cornerstone of modern synthetic organic chemistry, providing powerful tools for building complex carbon skeletons. This course provides a clear, mechanism-focused approach to understanding how these highly reactive compounds function. By the end, you will be able to predict the products of reactions involving common organometallic reagents and design synthetic pathways for target molecules. What you'll learn: * Understand the structure and fundamental reactivity of carbon-metal bonds in organic synthesis. * Master the preparation, mechanism, and applications of Grignard reagents for forming carbon-carbon bonds and synthesizing alcohols. * Apply Gilman reagents (organocuprates) in conjugate additions and highly selective coupling reactions. * Practice predicting reaction outcomes and understanding stereochemical implications when using organometallic compounds. * Design multi-step synthetic routes using organometallic reagents to create complex carbonyl and alcohol derivatives. The course begins with foundational concepts and terminology, defining key reagent classes and their unique properties. We then move into detailed, step-by-step reaction mechanisms and practical examples of synthesis planning. This course is designed for absolute beginners in organic chemistry or students needing a strong foundation in synthetic methods. No prior knowledge of organometallic compounds is required. Start building your synthesis skills today.